Bioengineered Phages for Precision TME Targeting and Therapy Delivery
Jeya Chelliah B.VSc Ph.D. This innovative research proposal introduces the use of bioengineered bacteriophages (phages) as a novel strategy to breach the TME barriers and enhance the delivery and efficacy of immunotherapies and other cancer treatments. Bacteriophages, viruses that infect bacteria, have been
The collection and analysis of exosomes
Jeya Chelliah B.VSc Ph.D. Collecting exosomes from cancer patients for diagnostic, prognostic, or therapeutic monitoring purposes involves a series of steps designed to isolate these nanoscale extracellular vesicles from various bodily fluids. The process is non-invasive or minimally invasive, making it an
Exploiting Exosomal miRNA Signatures for Real-Time Monitoring of Tumor Microenvironment Dynamics and Therapy Adjustment
Jeya Chelliah B.Vsc Ph.D. Exosomes, the nanoscale extracellular vesicles derived from the endosomal compartment of most eukaryotic cells, have emerged as significant players in intercellular communication. Through their cargo, which includes proteins, lipids, and various forms of RNA, exosomes influence numerous physiological and
Exosomes: Tiny Vesicles with Mammoth Potential in Cancer Diagnosis and Therapy Optimization
Jeya Chelliah B.Vsc Ph.D. In the vast and intricate world of cellular communication, exosomes have emerged as critical players with profound implications in the realm of life sciences, particularly in cancer research. These nanoscale extracellular vesicles are not just cellular debris; they are
Unlocking Research Success: Key Strategies for Productive Lab Meetings
Jeya Chelliah B.Vsc Ph.D. Lab meetings are a cornerstone of the scientific research process, providing a platform for sharing ideas, discussing progress, and fostering collaboration. However, the effectiveness of these meetings can vary widely, with the potential to either significantly boost productivity and
Revisiting the Past for Future Breakthroughs in Life Sciences
Jeya Chelliah B.Vsc Ph.D. In the ever-evolving field of life sciences, innovation is often viewed as a forward march towards the next groundbreaking discovery. However, a growing body of evidence suggests that revisiting past research and theories can be equally transformative. This approach
Exploring the Link: How Circadian Rhythms Influence Cancer Metabolism
Jeya Chelliah B.Vsc Ph.D. In the intricate ballet of cellular processes, circadian rhythms conduct the orchestra, ensuring that every biological function, from gene expression to metabolism, performs in harmony with the 24-hour cycle of day and night. This biological clock, deeply embedded in
New Strategies in Disease Control: Immunometabolism’s Role Against Cancer, Obesity, Diabetes, and Autoimmunity
Jeya Chelliah B.Vsc Ph.D. In the burgeoning field of immunometabolism, the intricate dance between immune cell function and metabolic pathways presents a frontier ripe for exploration. This relationship, central to the pathogenesis of diverse conditions such as cancer, obesity, diabetes, and autoimmune diseases,
Journey of Chemotherapy: From War Gases to Precision Medicine
Jeya Chelliah B.Vsc Ph.D. The discovery and evolution of chemotherapy represent one of the most fascinating chapters in the history of cancer treatment. This journey, from its accidental origins in chemical warfare to the sophisticated, targeted therapies of today, underscores a saga of
Exploring Quantum Computing and Synthetic Biology in the Fight Against Salmonella Typhi
Jeya Chelliah B.Vsc Ph.D In the realm of infectious diseases, Salmonella Typhi stands out for its resilience and adaptability, presenting significant challenges in treatment and prevention efforts. Traditional methodologies, while having made remarkable progress, are increasingly confronted with hurdles such as antibiotic resistance
