How MHC and Checkpoints Combat Cancer and Prevent Autoimmunity
Jeya Chelliah B.Vsc Ph.D. The human immune system is an intricate network designed to protect us from a myriad of pathogens. At the heart of this system lie two critical components: Major Histocompatibility Complex (MHC) molecules and immune checkpoint proteins. Both play pivotal
Bioengineered Phages for Precision TME Targeting and Therapy Delivery
Jeya Chelliah B.VSc Ph.D. This innovative research proposal introduces the use of bioengineered bacteriophages (phages) as a novel strategy to breach the TME barriers and enhance the delivery and efficacy of immunotherapies and other cancer treatments. Bacteriophages, viruses that infect bacteria, have been
Unveiling Similarities and Strategies to Breach TME, Infection Microenvironment, and TB Granuloma
Jeya Chelliah B.Vsc Ph.D. Comparing and contrasting the tumor microenvironment (TME), the infection microenvironment, and the tuberculosis (TB) granuloma reveals both unique and shared characteristics across these biological contexts. Understanding these environments is crucial for developing strategies to enhance immune cell access and
Bioengineered Phages for Precision TME Targeting and Therapy Delivery
Jeya Chelliah B.VSc Ph.D. This innovative research proposal introduces the use of bioengineered bacteriophages (phages) as a novel strategy to breach the TME barriers and enhance the delivery and efficacy of immunotherapies and other cancer treatments. Bacteriophages, viruses that infect bacteria, have been
The collection and analysis of exosomes
Jeya Chelliah B.VSc Ph.D. Collecting exosomes from cancer patients for diagnostic, prognostic, or therapeutic monitoring purposes involves a series of steps designed to isolate these nanoscale extracellular vesicles from various bodily fluids. The process is non-invasive or minimally invasive, making it an
Exploiting Exosomal miRNA Signatures for Real-Time Monitoring of Tumor Microenvironment Dynamics and Therapy Adjustment
Jeya Chelliah B.Vsc Ph.D. Exosomes, the nanoscale extracellular vesicles derived from the endosomal compartment of most eukaryotic cells, have emerged as significant players in intercellular communication. Through their cargo, which includes proteins, lipids, and various forms of RNA, exosomes influence numerous physiological and
Exosomes: Tiny Vesicles with Mammoth Potential in Cancer Diagnosis and Therapy Optimization
Jeya Chelliah B.Vsc Ph.D. In the vast and intricate world of cellular communication, exosomes have emerged as critical players with profound implications in the realm of life sciences, particularly in cancer research. These nanoscale extracellular vesicles are not just cellular debris; they are
Unlocking Research Success: Key Strategies for Productive Lab Meetings
Jeya Chelliah B.Vsc Ph.D. Lab meetings are a cornerstone of the scientific research process, providing a platform for sharing ideas, discussing progress, and fostering collaboration. However, the effectiveness of these meetings can vary widely, with the potential to either significantly boost productivity and
Revisiting the Past for Future Breakthroughs in Life Sciences
Jeya Chelliah B.Vsc Ph.D. In the ever-evolving field of life sciences, innovation is often viewed as a forward march towards the next groundbreaking discovery. However, a growing body of evidence suggests that revisiting past research and theories can be equally transformative. This approach
Exploring the Link: How Circadian Rhythms Influence Cancer Metabolism
Jeya Chelliah B.Vsc Ph.D. In the intricate ballet of cellular processes, circadian rhythms conduct the orchestra, ensuring that every biological function, from gene expression to metabolism, performs in harmony with the 24-hour cycle of day and night. This biological clock, deeply embedded in
