Spatial Transcriptomics Revolution: Advancing Diagnosis and Treatment through Precision Mapping
Jeya Chelliah B.Vsc Ph.D. In the ever-evolving landscape of biomedical research, a groundbreaking technology known as Spatial Transcriptomics is paving the way for unprecedented insights into the cellular composition of tissues. This innovative technique offers a detailed map of gene expression within tissue
How Single-Cell Sequencing Is Revolutionizing Our Understanding of Biology
Jeya Chelliah B.Vsc Ph,D. Single-cell sequencing (SCS) has catalyzed numerous groundbreaking discoveries across various fields of life sciences. This technology has revolutionized our understanding of the complexity and diversity of life at the cellular level. Here are some of the major discoveries facilitated
Could Single-Cell Sequencing Be the Future of Diagnostic Medicine?
Jeya Chelliah B.Vsc Ph.D. Single-cell sequencing (SCS) is a powerful genomic technology that allows researchers to examine the genetic material from individual cells, providing insights that are not possible with bulk sequencing, which averages data across many cells. This fine-grained analysis is crucial
How Plants Fine-Tune Their Immune Responses
Jeya Chelliah B.Vsc Ph.D. In the serene silence of gardens and forests, a relentless battle rages on at a scale invisible to the naked eye. Plants, often perceived as passive entities, are in constant combat with a myriad of pathogens that threaten their
Exploring ER Stress: From Cellular Balance to Cancer – New Therapeutic Insights
Jeya Chelliah B.Vsc Ph.D. The endoplasmic reticulum (ER) is a central hub of cellular activity, responsible for critical processes such as protein folding, lipid synthesis, and calcium storage and signaling. This multifunctional organelle plays a pivotal role in maintaining cellular health and integrity.
Adaptive Strategies for Scientists in the Face of Research Stalemates
Jeya Chelliah B.Vsc Ph.D. In the intricate dance of scientific discovery, not every step forward illuminates a new path. Researchers often encounter phases where, despite rigorous effort and dedication, their projects do not yield the anticipated constructive results. This scenario, far from signaling
Unlocking the Potential of Quantum Biophotonics and Nanotech in Cancer Therapy
Jeya Chelliah B.Vsc Ph.D. This novel research proposal introduces an interdisciplinary approach, integrating quantum physics, biophotonics, nanotechnology, and molecular biology, to develop a groundbreaking therapy for solid tumors. The core idea revolves around using quantum biophotonics to selectively disrupt the expression and function
How MHC and Checkpoints Combat Cancer and Prevent Autoimmunity
Jeya Chelliah B.Vsc Ph.D. The human immune system is an intricate network designed to protect us from a myriad of pathogens. At the heart of this system lie two critical components: Major Histocompatibility Complex (MHC) molecules and immune checkpoint proteins. Both play pivotal
Bioengineered Phages for Precision TME Targeting and Therapy Delivery
Jeya Chelliah B.VSc Ph.D. This innovative research proposal introduces the use of bioengineered bacteriophages (phages) as a novel strategy to breach the TME barriers and enhance the delivery and efficacy of immunotherapies and other cancer treatments. Bacteriophages, viruses that infect bacteria, have been
Unveiling Similarities and Strategies to Breach TME, Infection Microenvironment, and TB Granuloma
Jeya Chelliah B.Vsc Ph.D. Comparing and contrasting the tumor microenvironment (TME), the infection microenvironment, and the tuberculosis (TB) granuloma reveals both unique and shared characteristics across these biological contexts. Understanding these environments is crucial for developing strategies to enhance immune cell access and
