A Novel “Genomic Tag and Trap” Strategy to Overcome Neoantigen Evasion
Jeya Chelliah B.VSc Ph.D. Neoantigens are tumor-specific peptide fragments arising from somatic mutations in the cancer genome. By virtue of their absence in healthy tissues, these mutated peptides provide highly specific targets for immunotherapies such as personalized vaccines or T-cell receptor (TCR)–engineered cell
Harnessing ChatGPT-4.0 for Task Reminders: A Step Toward Intelligent AI Agents
Jeya Chelliah B.VSc Ph.D. The introduction of GPT-4.0 by OpenAI represents a major leap forward in conversational AI, with new and refined capabilities that extend beyond simple question-and-answer interactions. One noteworthy feature that has garnered growing attention is its capacity to handle task
Boost Research Innovation: Identify Knowledge Gaps with ChatGPT
Jeya Chelliah B.Vsc Ph.D. In today’s fast-paced scientific landscape, staying on top of the literature can be daunting. However, finding the right knowledge gap—a key piece of missing information—can spark innovative ideas for your next research project, grant proposal, or high-impact publication. This
Harnessing “Vigilance Saturation”: How Cancer Might Mimic Ecosystem Dynamics to Evade Immune Detection
Jeya Chelliah B.Vsc Ph.D. In nature, the survival strategies of various species often hold surprising parallels to the ways cancer cells interact with the immune system. One striking illustration can be found in large schools of sardines: by overwhelming predators with synchronized, frantic
Predator-Prey Camouflage: Cancer’s Molecular “Costume Party”
Jeya Chelliah B.Vsc Ph.D. In ecology, prey species deploy camouflage to go undetected by predators—chameleons shift their skin pigmentation, insects mimic leaves or twigs, and cuttlefish modulate their patterns in near-real-time. Translating these ideas to cancer biology raises a provocative hypothesis: what if
Reimagining Life Science Frontiers: Why Synthetic Biology Deserves Top Priority in the New Year
Jeya Chelliah B.Vsc PhD. As we stand at the cusp of a new year, it is fitting to reflect on the most promising avenues in life science research that could deliver transformative benefits for humanity. One particularly compelling domain poised to reshape medicine,
Rethinking Cancer: Reprogramming Cells and the Tumor Microenvironment for Lasting Remission
Jeya Chelliah B.VSc Ph.D. A novel and promising frontier in cancer therapy involves moving beyond attacking cancer cells directly and instead reprogramming both cancer and immune cells at a fundamental, intracellular level. This reprogramming can harness the full power of the immune system
Pioneering CRISPR 3.0: Multiplex Genome Editing for Rare Disease Cures
Jeya Chelliah B.VSc Ph.D. One of the most promising research endeavors currently underway in the life sciences is the development of next-generation CRISPR-based multiplex genome editing tools, often called “CRISPR 3.0.” Building on the foundational discoveries that established CRISPR-Cas systems as a powerful
A Visionary Concept: The “IntelliChip” for Continuous Cancer Surveillance and Real-Time Treatment
Jeya Chelliah B.Vsc Ph.D. One cutting-edge idea with the potential to transform early diagnosis and treatment of cancer is the creation of an implantable “IntelliChip”—a miniature, bio-integrated micro-lab that continuously monitors biochemical and cellular signals in the body and adjusts therapy in real
Bioengineered “Tumor Sponges” to Revolutionize Cancer Therapy
Jeya Chelliah B.Vsc Ph.D. In the relentless quest to outwit cancer, scientists are pushing the boundaries of imagination to design novel therapeutic strategies. One such innovative concept is the development of bioengineered “tumor sponges,” a potentially groundbreaking approach aimed at reprogramming the tumor
