eBook: CRISPR Epigenetic Immunotherapy

By Jeya Chelliah, B.VSc, Ph.D | Published by eScience 📘 About the Author Dr. Jeya Chelliah, Ph.D. in Biochemistry & Immunology from King’s College London, is a cancer researcher and the Editor of eScience, an online scientific publication recognized for delivering innovative research

Navigating Research Continuity During Funding Pauses: Smart Strategies for Life Scientists

Jeya Chelliah B.Vsc Ph.D The recent funding pause introduced across all scientific disciplines in the United States has sent a wave of uncertainty through the research community. Life science research, particularly in cancer biology, is especially vulnerable due to its dependence on sustained

Next-Gen Cancer Research: 50 Novel CRISPR & Epigenetic Ideas to Unlock Hidden Neoantigens

🚀 Are you ready to explore game-changing ideas that could revolutionize cancer research? The next breakthrough in cancer immunotherapy depends on uncovering hidden neoantigens—tumor-specific markers that enable precise immune attacks. But many remain silenced or weakly immunogenic, limiting today’s therapies. Now, for the

CRISPR Spotlight: Boosting Neoantigen Visibility to Outsmart Tumor Immune Evasion

Jeya Chelliah B.Vsc Ph.D. In the ever-evolving landscape of cancer immunotherapy, one of the most formidable challenges is the immune evasion tactics employed by tumor cells. These cells thrive within the immunosuppressive microenvironment of the tumor, effectively concealing their neoantigens from immune surveillance.

Mechanotransduction: A New Tool for Early Cancer Diagnosis and Treatment

Jeya Chelliah B.Vsc Ph.D. When you press a piano key, the instrument transforms your mechanical touch into melodious sound. Similarly, cells possess a remarkable ability to convert mechanical forces into biochemical signals through a process called mechanotransduction. While this process is crucial for

A Novel “Genomic Tag and Trap” Strategy to Overcome Neoantigen Evasion

Jeya Chelliah B.VSc Ph.D.  Neoantigens are tumor-specific peptide fragments arising from somatic mutations in the cancer genome. By virtue of their absence in healthy tissues, these mutated peptides provide highly specific targets for immunotherapies such as personalized vaccines or T-cell receptor (TCR)–engineered cell

Harnessing ChatGPT-4.0 for Task Reminders: A Step Toward Intelligent AI Agents

Jeya Chelliah B.VSc Ph.D. The introduction of GPT-4.0 by OpenAI represents a major leap forward in conversational AI, with new and refined capabilities that extend beyond simple question-and-answer interactions. One noteworthy feature that has garnered growing attention is its capacity to handle task

Boost Research Innovation: Identify Knowledge Gaps with ChatGPT

Jeya Chelliah B.Vsc Ph.D. In today’s fast-paced scientific landscape, staying on top of the literature can be daunting. However, finding the right knowledge gap—a key piece of missing information—can spark innovative ideas for your next research project, grant proposal, or high-impact publication. This

Harnessing “Vigilance Saturation”: How Cancer Might Mimic Ecosystem Dynamics to Evade Immune Detection

Jeya Chelliah B.Vsc Ph.D. In nature, the survival strategies of various species often hold surprising parallels to the ways cancer cells interact with the immune system. One striking illustration can be found in large schools of sardines: by overwhelming predators with synchronized, frantic

Predator-Prey Camouflage: Cancer’s Molecular “Costume Party”

Jeya Chelliah B.Vsc Ph.D. In ecology, prey species deploy camouflage to go undetected by predators—chameleons shift their skin pigmentation, insects mimic leaves or twigs, and cuttlefish modulate their patterns in near-real-time. Translating these ideas to cancer biology raises a provocative hypothesis: what if