How do you target a hostile soldier hiding in a crowd of peacekeepers when they wear the exact same uniform? In Glioblastoma, infiltrating macrophages and resident microglia share the same surface markers (Iba1, CD11b) but play opposing roles. Current therapies kill both, leaving the brain vulnerable. In this deep dive, we explore a hypothetical solution: a “Logic-Gated” PROTAC that uses intracellular Boolean logic to distinguish friend from foe.
Read More
